The Combination of Tripe Palms, Acanthosis Nigricans and Florid Cutaneous Papillomatosis in a Patient with Metastatic Cervical Cancer

Tripe palms, which described the thickening of pamar skin with increase of normal dermatoglyphics and a peculiar velvety texture, is a specific cutaneous paraneoplastic syndrome especially related to cancers of upper aerodigestive tract. Acanthosis nigricans, and florid cutaneous papillomatosis (sudden appearance of many warty skin lesions) are the most commonly associated paraneoplastic dermatosis. All three may be part of a continuum, caused by factors produced by the underlying malignancy. A thorough investigation for an underlying malignancy is warranted for all patients with tripe palms and / or florid cutaneous papillomatosis. We reported a 55-year-old female initially presented with tripe palms. After detailed cutaneous survey, acanthosis nigricans and florid cutaneous papillomatosis were also found. Thorough examinations revealed recurrence and metastasis of her cervical cancer. (Dermatol Sinica 22 : 142-147, 2004)